DISEASES

Disease-gene associations mined from literature

Literature associating CILP and bone deterioration disease

CILP [ENSP00000261883]

Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage; Immunoglobulin like domain containing

Synonyms:  CILP,  O75339,  O75339p,  hO75339,  UNQ602/PRO1188 ...

Linkouts:  STRING  Pharos  UniProt  OMIM