Literature associating APH1B and ITM2B-related cerebral amyloid angiopathy 2
Presenilin-stabilization factor-like; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Synonyms: APH1B, APH1Bp, hAPH1B, APH-1B, H0YKZ9 ...