DISEASES

Disease-gene associations mined from literature

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Literature associating SPG11 and hereditary spastic paraplegia 35

SPG11 [ENSP00000261866]

Spastic paraplegia 11 (autosomal recessive); May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.

Synonyms:  SPG11,  SPG11p,  hSPG11,  C4B7M2,  C4B7M3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.