Literature associating TRMT5 and thiamine-responsive megaloblastic anemia syndrome
tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Synonyms: TRMT5, TRMT5p, hTRMT5, G3V494, G3V5X1 ...