DISEASES

Disease-gene associations mined from literature

Literature associating CYP2C9 and sulfonamide allergy

CYP2C9 [ENSP00000260682]

Cytochrome P450, family 2, subfamily C, polypeptide 9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Synonyms:  CYP2C9,  CYP2C9p,  hCYP2C9,  P11712,  Q9UEH3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM