DISEASES

Disease-gene associations mined from literature

Literature associating THBS1 and bone giant cell tumor

THBS1 [ENSP00000260356]

Thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Synonyms:  THBS1,  THBS1p,  hTHBS1,  A0PJG0,  A8MZG1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM