Literature associating POU5F1 and embryonal cancer
POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Synonyms: POU5F1, POU5F1p, hPOU5F1, OCT3, OCT4 ...