DISEASES

Disease-gene associations mined from literature

Literature associating TFCP2 and spindle cell rhabdomyosarcoma

TFCP2 [ENSP00000257915]

Alpha-globin transcription factor CP2; Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter; Belongs to the grh/CP2 family. CP2 subfamily.

Synonyms:  TFCP2,  TFCP2p,  hTFCP2,  A0A024R120,  F8VWL0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM