DISEASES

Disease-gene associations mined from literature

Literature associating TRAFD1 and central nervous system tuberculosis

TRAFD1 [ENSP00000257604]

TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).

Synonyms:  TRAFD1,  TRAFD1p,  hTRAFD1,  A0A024RBK4,  B4DI89 ...

Linkouts:  STRING  Pharos  UniProt  OMIM