DISEASES

Disease-gene associations mined from literature

Literature associating KLB and functional diarrhea

KLB [ENSP00000257408]

Klotho beta-like protein; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

Synonyms:  KLB,  Q86Z14,  Q86Z14p,  hQ86Z14,  152831 ...

Linkouts:  STRING  Pharos  UniProt  OMIM