DISEASES

Disease-gene associations mined from literature

Literature associating DOCK2 and Usher syndrome type 1C

DOCK2 [ENSP00000256935]

Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2; Belongs to the DOCK family.

Synonyms:  DOCK2,  DOCK2p,  hDOCK2,  B3KXW9,  E5RFJ0 ...

Linkouts:  STRING  Pharos  UniProt