Literature associating DOCK2 and Usher syndrome type 1C
Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2; Belongs to the DOCK family.
Synonyms: DOCK2, DOCK2p, hDOCK2, B3KXW9, E5RFJ0 ...