DISEASES

Disease-gene associations mined from literature

Literature associating KIDINS220 and frontal sinus neoplasm

KIDINS220 [ENSP00000256707]

Ankyrin repeat-rich membrane-spanning protein; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway; Ankyrin repeat domain containing

Synonyms:  KIDINS220,  B4DG84,  B4DGY1,  B4DK94,  E9PH70 ...

Linkouts:  STRING  Pharos  UniProt  OMIM