Literature associating NR1H2 and acute promyelocytic leukemia
Nuclear receptor subfamily 1, group H, member 2; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Belongs to the nuclear hormone receptor family. NR1 subfamily.
Synonyms: NR1H2, NR1H2p, hNR1H2, B3KRG6, F1D8P7 ...