DISEASES

Disease-gene associations mined from literature

Literature associating NR1H2 and acute promyelocytic leukemia

NR1H2 [ENSP00000253727]

Nuclear receptor subfamily 1, group H, member 2; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity; Belongs to the nuclear hormone receptor family. NR1 subfamily.

Synonyms:  NR1H2,  NR1H2p,  hNR1H2,  B3KRG6,  F1D8P7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM