Literature associating MAS1 and optic atrophy 11
MAS1 proto-oncogene, G protein-coupled receptor; Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Synonyms: MAS1, MAS1p, hMAS1, MGRA, P04201 ...