DISEASES

Disease-gene associations mined from literature

Literature associating ALOX12 and acute pericementitis

ALOX12 [ENSP00000251535]

Arachidonate 12-lipoxygenase, 12S-type; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation; Belongs to the lipoxygenase family.

Synonyms:  ALOX12,  ALOX12p,  hALOX12,  ALOX12-001,  ALOX12-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM