DISEASES

Disease-gene associations mined from literature

Literature associating CHRNA10 and nicotine dependence

CHRNA10 [ENSP00000250699]

Cholinergic receptor, nicotinic, alpha 10 (neuronal); Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma; Cholinergic receptors nicotinic subunits

Synonyms:  CHRNA10,  CHRNA10p,  hCHRNA10,  E9PNT7,  E9PNX2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM