DISEASES

Disease-gene associations mined from literature

Literature associating PARP2 and arthrogryposis, renal dysfunction, and cholestasis 1

PARP2 [ENSP00000250416]

ADP-ribosyltransferase diphtheria toxin-like 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity; Poly(ADP-ribose) polymerases

Synonyms:  PARP2,  PARP2p,  hPARP2,  E9PJ27,  G3V167 ...

Linkouts:  STRING  Pharos  UniProt  OMIM