Literature associating PARP2 and arthrogryposis, renal dysfunction, and cholestasis 1
PARP2 [ENSP00000250416]
ADP-ribosyltransferase diphtheria toxin-like 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity; Poly(ADP-ribose) polymerases
Synonyms: PARP2, PARP2p, hPARP2, E9PJ27, G3V167 ...