DISEASES

Disease-gene associations mined from literature

Literature associating TICAM1 and encephalitis

TICAM1 [ENSP00000248244]

Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Synonyms:  TICAM1,  TICAM1p,  hTICAM1,  Q8IUC6,  PRVTIRB ...

Linkouts:  STRING  Pharos  UniProt  OMIM