DISEASES

Disease-gene associations mined from literature

Literature associating TAS2R4 and cerebellar ataxia type 9

TAS2R4 [ENSP00000247881]

Taste receptor, type 2, member 4; Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.

Synonyms:  TAS2R4,  TAS2R4p,  hTAS2R4,  HOSA(ADYGEI)-T2R4,  HOSA(BIAKA)-T2R4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM