DISEASES

Disease-gene associations mined from literature

Literature associating TRAP1 and brain glioblastoma multiforme

TRAP1 [ENSP00000246957]

Tumor necrosis factor type 1 receptor-associated protein; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA; Belongs to the heat shock protein 90 family.

Synonyms:  TRAP1,  LOC101929751,  TRAP1p,  hTRAP1,  I3L0K7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM