DISEASES

Disease-gene associations mined from literature

Literature associating SLURP1 and keratosis

SLURP1 [ENSP00000246515]

Secreted LY6/PLAUR domain containing 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU- dependent functions of PLAUR such as in cell migration and proliferation; LY6/PLAUR domain containing

Synonyms:  SLURP1,  SLURP1p,  hSLURP1,  P55000,  ARS ...

Linkouts:  STRING  Pharos  UniProt  OMIM