DISEASES

Disease-gene associations mined from literature

Literature associating HIST1H4F and familial hyperinsulinemic hypoglycemia 1

HIST1H4F [ENSP00000244537]

Histone cluster 1, H4f; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Synonyms:  HIST1H4F,  HIST1H4G,  Q99525,  H4FL,  H4/L ...

Linkouts:  STRING  Pharos  UniProt  OMIM