Disease-gene associations mined from literature

Literature associating SNAI1 and cercarial dermatitis

SNAI1 [ENSP00000244050]

Snail family zinc finger 1; Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself; Belongs to the snail C2H2-type zinc-finger protein family.

Synonyms:  SNAI1,  SNAI1p,  hSNAI1,  O95863,  O95863p ...

Linkouts:  STRING  Pharos  UniProt  OMIM