DISEASES

Disease-gene associations mined from literature

Literature associating LRP1 and esophageal varix

LRP1 [ENSP00000243077]

Prolow-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2- macroglobulin receptor; Belongs to the LDLR family.

Synonyms:  LRP1,  LRP1p,  hLRP1,  H0YJ88,  LRP ...

Linkouts:  STRING  Pharos  UniProt