Disease-gene associations mined from literature

Literature associating POLK and prostate cancer

POLK [ENSP00000241436]

Polymerase (DNA directed) kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.

Synonyms:  POLK,  LOC102725405,  A0A024RAP4,  D6R9M8,  D6RAE5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM