DISEASES

Disease-gene associations mined from literature

Literature associating ACVR2A and fibrodysplasia ossificans progressiva

ACVR2A [ENSP00000241416]

Activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Synonyms:  ACVR2A,  ACVR2Ap,  hACVR2A,  P27037,  ACVR2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM