DISEASES

Disease-gene associations mined from literature

Literature associating EGR1 and fibrosarcoma

EGR1 [ENSP00000239938]

Nerve growth factor-induced protein A; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double- stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity); Zinc fingers C2H2-type

Synonyms:  EGR1,  EGR1p,  hEGR1,  P18146,  Q546S1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM