Disease-gene associations mined from literature

Literature associating NEK9 and nephronophthisis 12

NEK9 [ENSP00000238616]

Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

Synonyms:  NEK9,  NEK9p,  hNEK9,  G3V2Z5,  G3V459 ...

Linkouts:  STRING  Pharos  UniProt  OMIM