DISEASES

Disease-gene associations mined from literature

Literature associating FGF23 and hyperphosphatemic familial tumoral calcinosis

FGF23 [ENSP00000237837]

Tumor-derived hypophosphatemia-inducing factor; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Synonyms:  FGF23,  FGF23p,  hFGF23,  Q9GZV9,  HYPF ...

Linkouts:  STRING  Pharos  UniProt  OMIM