Disease-gene associations mined from literature

Literature associating MED28 and chronic intestinal vascular insufficiency

MED28 [ENSP00000237380]

Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.

Synonyms:  MED28,  MED28p,  hMED28,  H0YAA8,  Q9H204 ...

Linkouts:  STRING  Pharos  UniProt  OMIM