Disease-gene associations mined from literature

Literature associating OPRD1 and agnosia

OPRD1 [ENSP00000234961]

Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Synonyms:  OPRD1,  OPRD1p,  hOPRD1,  D2CGC9,  P41143 ...

Linkouts:  STRING  Pharos  UniProt  OMIM