Literature associating PRTN3 and primary sclerosing cholangitis
Neutrophil proteinase 4; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177; Belongs to the peptidase S1 family. Elastase subfamily.
Synonyms: PRTN3, PRTN3p, hPRTN3, P24158, ACPA ...