DISEASES

Disease-gene associations mined from literature

Literature associating DOK1 and chronic myeloid leukemia

DOK1 [ENSP00000233668]

Docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Synonyms:  DOK1,  DOK1p,  hDOK1,  Q2TA81,  Q99704 ...

Linkouts:  STRING  Pharos  UniProt  OMIM