DISEASES

Disease-gene associations mined from literature

Literature associating GRM6 and retinal disease

GRM6 [ENSP00000231188]

Glutamate receptor, metabotropic 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors

Synonyms:  GRM6,  GRM6p,  hGRM6,  O15303,  GPRC1F ...

Linkouts:  STRING  Pharos  UniProt  OMIM