DISEASES

Disease-gene associations mined from literature

Literature associating FZD10 and fallopian tube serous adenocarcinoma

FZD10 [ENSP00000229030]

Frizzled class receptor 10; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Synonyms:  FZD10,  FZD10p,  hFZD10,  F5H450,  Q9ULW2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM