DISEASES

Disease-gene associations mined from literature

Literature associating SLC25A11 and aromatic L-amino acid decarboxylase deficiency

SLC25A11 [ENSP00000225665]

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity); Solute carriers

Synonyms:  SLC25A11,  I3L1P8,  Q02978,  Q6IBH0,  SLC25A11-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM