Disease-gene associations mined from literature

Literature associating MPO and primary sclerosing cholangitis

MPO [ENSP00000225275]

Myeloperoxidase; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily.

Synonyms:  MPO,  J3QSF7,  MPO-001,  MPO-002,  MPO-003 ...

Linkouts:  STRING  Pharos  UniProt  OMIM