DISEASES

Disease-gene associations mined from literature

Literature associating C5 and complement component 5 deficiency

C5 [ENSP00000223642]

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled; C3 and PZP like, alpha-2-macroglobulin domain containing

Synonyms:  C5,  C5p,  hC5,  C5-001,  C5-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM