DISEASES

Disease-gene associations mined from literature

Literature associating FIS1 and skin amelanotic melanoma

FIS1 [ENSP00000223136]

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission; Belongs to the FIS1 family.

Synonyms:  FIS1,  FIS1p,  hFIS1,  C9JXH1,  F5H509 ...

Linkouts:  STRING  Pharos  UniProt  OMIM