Literature associating AIMP2 and early infantile epileptic encephalopathy 29
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Synonyms: AIMP2, AIMP2p, hAIMP2, A0A024QZY1, A8MU58 ...