DISEASES

Disease-gene associations mined from literature

Literature associating NAMPT and obesity

NAMPT [ENSP00000222553]

Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity); Belongs to the NAPRTase family.

Synonyms:  NAMPT,  A0A024R718,  C9JF35,  C9JG65,  DKFZP666B131 ...

Linkouts:  STRING  Pharos  UniProt  OMIM