DISEASES

Disease-gene associations mined from literature

Literature associating PON1 and cerebrovascular disease

PON1 [ENSP00000222381]

Serum paraoxonase/arylesterase 1; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation; Belongs to the paraoxonase family.

Synonyms:  PON1,  PON1p,  hPON1,  F8WF42,  P27169 ...

Linkouts:  STRING  Pharos  UniProt  OMIM