Literature associating CRX and eye degenerative disease
Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family.
Synonyms: CRX, A4GUB7, CRX-001, CRX-004, CRX-005 ...