DISEASES

Disease-gene associations mined from literature

Literature associating EBI3 and autoimmune glomerulonephritis

EBI3 [ENSP00000221847]

Epstein-Barr virus-induced gene 3 protein; Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines; Fibronectin type III domain containing

Synonyms:  EBI3p,  hEBI3,  EBI3-001,  EBI3-002,  Q14213 ...

Linkouts:  STRING  Pharos  UniProt  OMIM