DISEASES

Disease-gene associations mined from literature

Literature associating CYP4F2 and warfarin resistance

CYP4F2 [ENSP00000221700]

Cytochrome P450, family 4, subfamily F, polypeptide 2; Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation. Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control. Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4); Belongs to the cytochrome P450 family.

Synonyms:  CYP4F2,  CYP4F2p,  hCYP4F2,  A0A024R7K3,  K7EK90 ...

Linkouts:  STRING  Pharos  UniProt  OMIM