DISEASES

Disease-gene associations mined from literature

Literature associating TNFRSF10A and cartilage disease

TNFRSF10A [ENSP00000221132]

Tumor necrosis factor receptor superfamily, member 10a; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B; CD molecules

Synonyms:  TNFRSF10A,  E5RFH1,  F8U8C0,  O00220,  TNFRSF10A-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM