DISEASES

Disease-gene associations mined from literature

Literature associating PLAT and acute pulmonary heart disease

PLAT [ENSP00000220809]

Tissue-type plasminogen activator; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Synonyms:  PLAT,  B4DN26,  B4DNJ1,  E5RGA1,  E5RHG4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM