Literature associating PLAT and patent foramen ovale
Tissue-type plasminogen activator; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Synonyms: PLAT, B4DN26, B4DNJ1, E5RGA1, E5RHG4 ...