DISEASES

Disease-gene associations mined from literature

Literature associating SFRP1 and colorectal adenoma

SFRP1 [ENSP00000220772]

Secreted apoptosis-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Synonyms:  SFRP1,  SFRP1p,  hSFRP1,  A8KAM5,  FRP1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM