Disease-gene associations mined from literature

Literature associating GZMB and nasal cavity lymphoma

GZMB [ENSP00000216341]

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis; Belongs to the peptidase S1 family. Granzyme subfamily.

Synonyms:  GZMB,  E7EUV0,  E9PID1,  E9PLX4,  E9PRD7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM